OxStem Neuro will identify a new class of drugs that will stimulate de novo neuron production from neural stem cells that will compensate for disease pathology in neurodegenerative diseases, such as Parkinson's disease, and restore cognitive function.
There are drug treatments for Parkinson's disease that can temporarily alleviate some symptoms or slow down their progression in some people, however OxStem Neuro’s approach aims to significantly reduce the impact of the disease on cognitive function, by replenishing the lost neurons.
Two main nests of neural stem cells in the brain have been identified in the Subventricular Zone and the Dentate Gyrus of the hippocampus. OxStem Neuro will identify small molecules to enhance this already present regenerative capacity. This will greatly improve the standard of living of those with the disease and would mark a large improvement over current treatments for the disease.